Association of diabetes with cardiovascular calcification and all-cause mortality in end-stage renal disease in the early stages of hemodialysis: a retrospective cohort study
Main finding · Cardiovascular calcificationResult — go to the resultOdds ratio 5.66 95% CI 1.96–16.36Authors' conclusion
In patients with ESRD during the early period of haemodialysis, diabetes significantly increases the risk of cardiovascular calcification, particularly multisite calcification, which is correlated with a higher mortality rate. The risk scores and nomograms developed in this study can assist clinicians in predicting the risk of death and providing individualised treatment plans to lower mortality rates in the early stages of hemodialysis.
Study context
- Population
- End-stage renal disease (ESRD) patients in the early stages of hemodialysis
- Participants
- 285 patients
- Exposure
- Diabetes vs no diabetes
- Diabetesn = 101
- Nondiabeticn = 184reference
- Outcome
- All-cause mortality, as affected by diabetes, cardiovascular calcification and other risk factors
Main finding
Cardiovascular calcification
Odds ratio
5.66
95% CI 1.96–16.36
P < 0.001
Events by group
As reported in the abstract
Observational data: associations, not effects.
Further findings
All-cause mortality
- Overall mortality rate
- 14.7% (42/285)
- Mortality with both diabetes and calcification
- 29.27%, 24/82
- Diabetes and calcification, with other factors, collectively predict death risk
Biochemistry
- Diabetic patients had lower phosphorus, calcium, calcium-phosphorus product, plasma PTH and albumin levels
- P < 0.001
Nomogram model performance · 5 years
- AUC
- 0.975
- Outstanding calibration at low to high-risk levels; greatest net benefit across a wide range of decision thresholds
Original publication
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