Normoalbuminuria—is it normal? The association of urinary albumin within the ‘normoalbuminuric’ range with adverse cardiovascular and mortality outcomes: A systematic review and meta‐analysis
Authors' conclusion
We propose considering higher UACR within the normoalbuminuric range as a prognostic factor for cardiovascular morbidity and mortality. Our findings underscore the clinical significance of even mild increases in albuminuria.
Study context
- Population
- Real-world prospective and retrospective cohort studies of urinary albumin-to-creatinine ratio (UACR) categories <30 mg/g and CV outcomes or mortality (PubMed, Embase)22 manuscripts, 15 meta-analysed
- Comparison
- UACR categories within the normal range
- Outcome
- Mortality and CV outcomes by UACR category
Methodological detailsrandom effects meta-analysis, prospective and retrospective cohort studies
- Random effects meta-analysis
- Prospective and retrospective cohort studies
Pooled result
As reported in the abstract
Hazard ratio (95% CI)
UACR 10-30 mg/gvs UACR <10 mg/gall-cause mortality
1.41(1.15–1.74)
UACR 10-30 mg/gvs UACR <10 mg/gcoronary heart disease
1.56(1.23–1.98)
UACR 10-30 mg/gvs UACR <5 mg/gCV mortality
2.12(1.61–2.80)
UACR 5-10 mg/gvs UACR <5 mg/gall-cause mortality
1.14(1.05–1.24)
UACR 5-10 mg/gvs UACR <5 mg/gCV mortality
1.50(1.14–1.99)
Original publication
Normoalbuminuria—is it normal? The association of urinary albumin within the ‘normoalbuminuric’ range with adverse cardiovascular and mortality outcomes: A systematic review and meta‐analysis. Diabetes Obes Metab. Published 17 July 2024. doi:10.
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