Bidirectional Associations Between Mental Health Disorders and Chronic Diabetic Complications in Individuals With Type 1 or Type 2 Diabetes
Authors' conclusion
We found a consistent bidirectional association between CDCs and MHDs across the life span, highlighting the important relationship between CDCs and MHDs. Prevention and treatment of either comorbidity may help reduce the risk of developing the other.
Study context
- Population
- Matched individuals with T1D, T2D or without diabetes in a nationally representative US-type health care claims database, 2001–2018matched cohort
- Participants
- 553,552 individuals
- Exposure
- Bidirectional association between chronic diabetes complications (CDCs) and mental health disorders (MHDs); T1D vs T2D vs no diabetes
- Type 1 diabetesn = 44,735
- Type 2 diabetesn = 152,187
- Without diabetesn = 356,630reference
- Outcome
- Hazard of developing MHDs after CDCs, and of developing CDCs after MHDs
Methodological detailsnationally representative health care claims database, propensity score quasirandomization, stratified by age (0-19, 20-39, 40-59, and ≥60 years), Cox proportional hazards models with time-varying diagnoses
- Nationally representative health care claims database
- Propensity score quasirandomization
- Stratified by age (0-19, 20-39, 40-59, and ≥60 years)
- Cox proportional hazards models with time-varying diagnoses
Main finding
As reported in the abstract
Bidirectional association between CDCs and MHDs
Having a CDC increased the hazard of developing an MHD (higher HRs in older age strata)
HR 1.9-2.9
P < 0.05
Having an MHD increased the hazard of developing a CDC (highest HR in age stratum 0-19 years)
HR 1.4-2.5
P < 0.05
Observational data: associations, not effects.
Further findings
Diabetes type and CDCs/MHDs, age <60 years
- T1D more likely to have CDCs; T2D more likely to have MHDs
Effect of diabetes type on the CDC–MHD relationship
- Relationship between CDCs and MHDs in either direction not affected by diabetes type
- P > 0.05 for interaction effects
Original publication
Bidirectional Associations Between Mental Health Disorders and Chronic Diabetic Complications in Individuals With Type 1 or Type 2 Diabetes. Diabetes Care. Published 15 July 2024. doi:10.
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