The associations of body mass index and waist circumference with the risk of diabetic complications in people with type 2 diabetes mellitus
Authors' conclusion
BMI/WC had both positive and negative associations with diabetic complications. Therefore, each patient's BMI/WC target should be carefully determined for each diabetic complication, considering the risk of developing other diseases.
Study context
- Population
- People with T2D, nationwide Japanese medical claims database; 82% male; mean age 52.52 ± 8.27 years
- Participants
- 114,254 people
- Exposure
- Body mass index (BMI) and waist circumference (WC) categories
- Outcome
- Severe diabetic complications: treatment-requiring diabetic eye disease (TRDED), dialysis initiation, coronary artery disease (CAD), cerebrovascular disease, HF and amputation
- Follow-up
- Median 4.64 years
Methodological detailsnationwide medical claims database, multivariate-adjusted Cox proportional models
- Nationwide medical claims database
- Multivariate-adjusted Cox proportional models
Main finding
As reported in the abstract
Severe diabetic complications by BMI/WC
- Treatment-requiring diabetic eye disease (TRDED), men with WC ≥ 95 cm
- HR = 0.79, 95% CI = 0.69-0.91
- Coronary artery disease (CAD), men with BMI < 20.0 kg/m²
- HR = 0.68, 95% CI = 0.49-0.94
- Cerebrovascular disease (CVD) with abdominal obesity
- HR = 1.36, 95% CI = 1.08-1.70
- Dialysis with BMI ≥ 25 kg/m²/WC ≥ 90 cm
- HR = 0.42, 95% CI = 0.29-0.62
- Heart failure (HF) with BMI ≥ 25 kg/m²/WC ≥ 90 cm
- HR = 1.33, 95% CI = 1.03-1.72
Observational data: associations, not effects.
Original publication
The associations of body mass index and waist circumference with the risk of diabetic complications in people with type 2 diabetes mellitus. Diabetes Obes Metab. Published 16 May 2025. doi:10.
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