Association between depression and the development of end‐stage kidney disease in people with diabetes: A population‐based cohort study
Authors' conclusion
After accounting for the competing risk of death, depression was associated with a lower observed cumulative incidence of ESKD.
Study context
- Population
- Adults aged ≥ 18 years with diabetes and CKD stages 1–4, UK primary care (Clinical Practice Research Datalink); mean age 76.8 ± 10.2 years, 45.5% male, 14.3% with depression
- Participants
- 58,769 adults
- Exposure
- Depression vs no depression
- Outcome
- Progression to ESKD
- Follow-up
- Mean 5.6 ± 3.4 years
Methodological detailscompeting risk analysis, adjusted for demographic, socioeconomic and clinical characteristics
- Competing risk analysis
- Adjusted for demographic, socioeconomic and clinical characteristics
Main finding
As reported in the abstract
Each group vs no depressionEstimate (95% CI)
Depression
SHR (crude) 0.67(0.57–0.78)
Depression
SHR (adjusted) 0.82(0.68–0.99)
- Progressed to end-stage kidney disease (ESKD) (overall)
- 1720
- Died before ESKD (overall)
- 25,127
Observational data: associations, not effects.
Further findings
- Older age was associated with a lower cumulative incidence of ESKD
Original publication
Association between depression and the development of end‐stage kidney disease in people with diabetes: A population‐based cohort study. Diabet Med. Published 30 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →