Multi-modal characterisation of early-stage, subclinical cardiac deterioration in patients with type 2 diabetes
An erratum to this article was published (Cardiovasc Diabetol, 29 Jan 2025 ↗)
Authors' conclusion
T2DM prior to cardiovascular disease was linked with a higher heart rate, QTc prolongation, T wave amplitude reduction, as well as lower stroke volume and increased left ventricular wall thickness. Increased QRS duration and left ventricular wall thickness and mass were most strongly associated with future cardiovascular disease. Although subclinical, these changes may indicate the presence of autonomic dysfunction and diabetic cardiomyopathy.
Study context
- Population
- UK Biobank participants with and without T2D and no diagnosed CVD at assessment
- Participants
- 1,781 participants2 matched cohorts
- Exposure
- T2D vs no T2D
- Outcome
- ECG and cardiac MRI biomarkers
Methodological detailspair-matched, UK Biobank, multivariate multiple linear regression sequentially adjusted for socio-demographic, lifestyle and clinical covariates
- Pair-matched
- UK Biobank
- Multivariate multiple linear regression sequentially adjusted for socio-demographic, lifestyle and clinical covariates
Main finding
As reported in the abstract
Beta (heart rate)
3.11
95% CI 2.11,4.10P < 0.001
independently associated; higher heart rate
Beta (stroke volume)
−4.11
95% CI −6.03 to −2.19P < 0.001
independently associated; lower stroke volume
Beta (LV wall thickness)
0.133
95% CI 0.081,0.186P < 0.001
independently associated; higher LV wall thickness
Observational data: associations, not effects.
Further findings
Subgroups
- Trends consistent in subgroups of different sex, age and BMI
- Fewer significant differences in participants of non-white ethnic background
Association of biomarkers with development of CVD
- QRS duration and Sokolow-Lyon index positively associated with CVD development in cohorts with and without T2D, respectively
- Higher LV mass and wall thickness associated with cardiovascular outcomes in both groups
Original publication
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