Echocardiographic phenotypes of diabetic myocardial disorder: evolution over 15 months follow-up in the ARISE-HF trial
Authors' conclusion
Among individuals with T2DM and SBHF, reduced functional capacity is most prevalent in those with multiple physiological disturbances. However, there was no difference between phenogroups in the evolution of exercise intolerance.
Study context
- Population
- Patients with well-controlled T2D screened for stage B HF (abnormal echocardiography or biomarkers) in the ARISE-HF trial; age 67 ± 7 years, 50% womenwith diabetic myocardial disorder (DbMD)
- Participants
- 1,463 patients
- Comparison
- Four DbMD phenogroups: biomarkers alone, systolic dysfunction/hypertrophy, diastolic dysfunction, overlap
- Biomarkers alonen = 907
- Systolic dysfunction/hypertrophyn = 301
- Diastolic dysfunctionn = 162
- Overlapn = 93
Methodological detailsphase 3
- Phase 3
Primary result
As reported in the abstract
Reduced VO2 (< 75% predicted)
P < 0.0001
- Reduced VO2 overall
- 669 (46%)
Further findings
Change in VO2 · 15 months
- Similar small decrement in VO2 in all groups
- 669 patients followed
Original publication
Echocardiographic phenotypes of diabetic myocardial disorder: evolution over 15 months follow-up in the ARISE-HF trial. Cardiovasc Diabetol. Published 13 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →