Relationship between NT-proBNP, echocardiographic abnormalities and functional status in patients with subclinical siabetic cardiomyopathy
Authors' conclusion
Among patients with subclinical DbCM, elevated NT-proBNP concentrations are associated with worse health status, lower activity levels, and reduced functional capacity, but not with cardiac structural abnormalities. These findings suggest that regardless of cardiac structural abnormalities, biomarker concentrations reflect important deterioration in functional capacity in affected individuals.
Study context
- Population
- Participants with asymptomatic diabetic cardiomyopathy (DbCM) in the ARISE-HF trial
- Participants
- 685 participants
- Comparison
- Correlation of NT-proBNP (quartiles) with echocardiographic and functional parameters
Methodological detailsprespecified subgroup analysis
- Prespecified subgroup analysis
Primary result
As reported in the abstract
baseline
- Overall Kansas City Cardiomyopathy Questionnaire score
- rho = - 0.10; p = 0.007
- Physical Activity Scale in the Elderly
- rho = - 0.12; p = 0.004
- Duration of cardiopulmonary exercise testing
- rho = - 0.28; p < 0.001
- Peak VO2
- rho = - 0.26; p < 0.001
- Minute ventilation/carbon dioxide production ratio
- rho = 0.12; p = 0.002
Further findings
NT-proBNP · baseline
- Median NT-proBNP (Q1, Q3)
- 71 (33, 135) ng/L
Original publication
Relationship between NT-proBNP, echocardiographic abnormalities and functional status in patients with subclinical siabetic cardiomyopathy. Cardiovasc Diabetol. Published 2 August 2024. doi:10.
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