Relationship of Carbohydrate Intake Proportion to Cardiovascular Events in Japanese People With Type 2 Diabetes Mellitus
Main finding · Composite primary endpoint (CV events and all-cause mortality)Result — go to the resultHazard ratio 1.06 95% CI 1.02–1.10Authors' conclusion
Our data demonstrated that a higher proportion of carbohydrate intake, particularly with reduced consumption of animal-derived fat/protein, was correlated with an increased risk of cardiovascular disease and all-cause mortality. These data underscore the need to consider dietary components in people with type 2 diabetes.
Study context
- Population
- Japanese outpatients with T2D and no evident CVD history
- Participants
- 731 outpatients
- Exposure
- Mean proportion of carbohydrate intake and other lifestyle habits vs risk of CV events and all-cause mortality
- Outcome
- Composite of:
- CV events
- All-cause mortality
- Follow-up
- Mean 7.5 ± 2.4 years
Methodological detailsprospective observational, multivariable Cox proportional hazards model, Lifestyle habits, including diet, assessed by questionnaires at baseline and years 2 and/or 5; mean values used
- Prospective observational
- Multivariable Cox proportional hazards model
- Lifestyle habits, including diet, assessed by questionnaires at baseline and years 2 and/or 5; mean values used
Main finding
As reported in the abstract
Composite primary endpoint (CV events and all-cause mortality)
Hazard ratio
1.06
95% CI 1.02–1.10
P = 0.005
Mean proportion of carbohydrate intake and other lifestyle habitsvs risk of CV events and all-cause mortality
HR 1.06 (95% CI 1.02–1.10); P = 0.005
- Participants with composite primary endpoint events
- 55
Observational data: associations, not effects.
Original publication
Relationship of Carbohydrate Intake Proportion to Cardiovascular Events in Japanese People With Type 2 Diabetes Mellitus. J Clin Endocrinol Metab. Published 21 March 2025. doi:10.
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