Dysglycaemia is associated with the pattern of valvular calcification in micro-computed tomography analysis: an observational study in patients with severe aortic stenosis
Authors' conclusion
Strict glycaemic control could potentially reduce the rate of valve mineralization and calcium deposit accumulation in patients with AS.
Study context
- Population
- Patients with severe aortic stenosis (AS) undergoing surgical valve removal, without diabetes mellitus (DM) or antidiabetic agents
- Participants
- 15 vs 14
- Comparison
- Impaired and high glucose vs normoglycaemia
- Elevated glucosen = 15
- Normoglycaemicn = 14reference
- Outcome
- Micro-CT valvular calcification indices
Methodological detailsex vivo micro-computed tomography (micro-CT)
- Ex vivo micro-CT
Main finding
As reported in the abstract
Calcium volume (CV) higher with impaired and high glucose vs normoglycaemic
+ 127.6%
CV/surface volume (SV) ratio higher with impaired and high glucose vs normoglycaemic
+ 59%
Trabecular thickness (TbTh) higher with impaired and high glucose vs normoglycaemic
about 50%
Observational data: associations, not effects.
Further findings
HbA1c, AGEs and sRAGE
- HbA1c higher with impaired and high glucose
- + 17%
- AGEs higher with impaired and high glucose
- + 44.6%
- sRAGE not higher
Echocardiographic AS severity
- PGmax higher with impaired and high glucose
- 19.2%
- Vmax higher with impaired and high glucose
- 9.3%
- Micro-CT parameters associated with PGmean, PGmax, Vmax and aortic valve area (all p < 0.05)
Original publication
Dysglycaemia is associated with the pattern of valvular calcification in micro-computed tomography analysis: an observational study in patients with severe aortic stenosis. Cardiovasc Diabetol. Published 20 March 2025. doi:10.
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