Risk factors for Lipohypertrophy in People With Insulin-Treated Diabetes: A Systematic Meta-Analysis
Authors' conclusion
This systematic review with meta-analysis revealed that incorrect injection site rotation and needle reuse are the most substantial factors in developing lipohypertrophy.
Study context
- Population
- People with insulin-treated diabetes; studies of potential risk factors for lipohypertrophy (MEDLINE/PubMed, Embase, CENTRAL, 1990 to August 21, 2023)51 studies
- Outcome
- Risk factors for lipohypertrophy related to patient characteristics and insulin therapy (prevalence ORs and MDs)
Pooled result
As reported in the abstract
Risk factors for lipohypertrophy
Pooled odds ratio (95% CI)
Incorrect injection site rotationstrongest contributor
8.85(5.10–15.33)
Needle reuse
3.20(1.99–5.13)
Duration of insulin therapy >5 years
2.62(1.70–4.04)
>2 daily injections per day
2.27(1.58–3.25)
Per day, as printed
Original publication
Risk factors for Lipohypertrophy in People With Insulin-Treated Diabetes: A Systematic Meta-Analysis. J Diabetes Sci Technol. Published 20 March 2025. doi:10.
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