Relationship Between Lipohypertrophy, Glycemic Control, and Insulin Dosing: A Systematic Meta-Analysis
Authors' conclusion
These results suggest that overall glycemic control is worse in patients with lipohypertrophy than in those without this condition.
Study context
- Population
- Patients with diabetes receiving insulin therapy; English-language studies in MEDLINE/PubMed, Embase, CENTRAL, 1990 to January 20, 202337 studies
- Comparison
- Diabetic patients with vs without lipohypertrophy
- Outcome
- Glycemic control and insulin dosing
Pooled result
As reported in the abstract
Lipohypertrophy vs No lipohypertrophyEstimate (95% CI)
Lipohypertrophy
pOR, unexplained hypoglycemia 6.98(3.30–14.77)
Lipohypertrophy
pOR, overall hypoglycemia 6.65(1.37–32.36)
Lipohypertrophy
pOR, glycemic variability 5.24(2.68–10.23)
- Higher with lipohypertrophy
- MD, HbA1c 0.55 % (95% CI 0.23–0.87)
- Higher with lipohypertrophy
- MD, daily insulin consumption 7.68 IU (95% CI 5.31–10.06)
Original publication
Relationship Between Lipohypertrophy, Glycemic Control, and Insulin Dosing: A Systematic Meta-Analysis. Diabetes Technol Ther. Published 12 February 2024. doi:10.
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