Association between inflammatory biomarkers and mortality in individuals with type 2 diabetes: NHANES 2005–2018
Authors' conclusion
Some biomarkers such as NLR, MLR, SII, AISI, SIRI, and dNLR, are significantly associated with all-cause mortality and CCD mortality among U.S. adults with diabetes. The risk of both outcomes increased when the biomarkers surpassed a specific threshold.
Study context
- Population
- U.S. adults aged 20 or older with diabetes, followed until December 31, 2019
- Participants
- 6,412 adults
- Exposure
- Highest vs lowest quartile of inflammatory biomarkers
- Outcome
- All-cause mortality and cardio-cerebrovascular disease (CCD) mortality
Main finding
As reported in the abstract
All-cause mortality
Each group vs lowest quartileEstimate (95 % CI)
Highest quartile
HR (NLR) 1.99(1.54–2.57)
Highest quartile
HR (MLR) 1.93(1.46–2.54)
Highest quartile
HR (SII) 1.49(1.18–1.87)
Highest quartile
HR (SIRI) 2.32(1.81–2.96)
Highest quartile
HR (nLPR) 2.05(1.61–2.60)
Highest quartile
HR (dNLR) 1.94(1.51–2.49)
- Highest quartile
- HR (AISI) 1.73 (95 % CI 1.4 1-2.12)
Observational data: associations, not effects.
Further findings
- Biomarker above a certain threshold: higher risk of all-cause and cardio-cerebrovascular disease (CCD) mortality
- Log rank P < 0.05
Original publication
Association between inflammatory biomarkers and mortality in individuals with type 2 diabetes: NHANES 2005–2018. Diabetes Res Clin Pract. Published 10 February 2024. doi:10.
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