Associations between thyroid hormones and appendicular skeletal muscle index, and hand grip strength in people with diabetes: The KAMOGAWA-A study
Authors' conclusion
FT3/FT4 ratios may impact skeletal muscles in people with diabetes-particularly in males. Assessments of FT3/FT4 ratios may represent key indicators of muscle mass and strength in males.
Study context
- Population
- People with diabetes admitted to 3 hospitals in Japan (KAMOGAWA-A study); 480 female; median age 68 years, BMI 24.3 kg/m², diabetes duration 10 years, HbA1c 7.6 %
- Participants
- 1,135 people
- Outcome
- Associations of thyroid hormones with SMI and HGS
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
- Negative correlation between FT3/FT4 ratio and sarcopenia (low skeletal muscle index (SMI) and low hand grip strength (HGS)) in males but not in females
- p for interaction = 0.02
- Median SMI of the cohort
- 7.1 kg/m²
- Median HGS of the cohort
- 28.2 kg
Observational data: associations, not effects.
Original publication
Associations between thyroid hormones and appendicular skeletal muscle index, and hand grip strength in people with diabetes: The KAMOGAWA-A study. Diabetes Res Clin Pract. Published 10 February 2024. doi:10.
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