Higher Appendicular Skeletal Muscle Mass to Visceral Fat Area Ratio Associated With Reduced Risk of Prediabetes
Main finding · Prediabetes per higher SVRResult — go to the resultAdjusted odds ratio 0.24 95% CI 0.19–0.31Authors' conclusion
SVR showed a significant nonlinear association with prediabetes, with gender-specific diagnostic thresholds. Moreover, it demonstrated superior diagnostic capability compared to BMI and MFR for identifying prediabetes.
Study context
- Population
- Participants in the 2011–2018 National Health and Nutrition Examination Survey (NHANES)
- Participants
- 4,195 participants
- Exposure
- Higher vs lower SVR
- Outcome
- Prediabetes
Methodological detailsNHANES 2011-2018, weighted logistic regression, restricted cubic splines, mediation analysis
- NHANES 2011-2018
- Weighted logistic regression
- Restricted cubic splines
- Mediation analysis
Main finding
Prediabetes per higher SVR
Adjusted odds ratio
0.24
95% CI 0.19–0.31
Higher SVR
aOR 0.24 (95% CI 0.19–0.31)
Per higher SVR, as printed
As reported in the abstract
kg/cm²
- Nonlinear relationship; inflection point in males
- 0.334
- Nonlinear relationship; inflection point in females
- 0.199
Observational data: associations, not effects.
Further findings
| Outcome | SVR | BMI | MFR | Estimate |
|---|---|---|---|---|
| Diagnostic performance for prediabetes (weighted ROC), males | ||||
| AUC | 0.653 | 0.614 | 0.605 | |
| Diagnostic performance for prediabetes (weighted ROC), females | ||||
| AUC | 0.689 | 0.651 | 0.619 | |
| Association of SVR with 2-h OGTT glucose and FPGSVR | β, 2-h OGTT glucose −0.44 (95% CI −0.52 to −0.36) | |||
| Association of SVR with 2-h OGTT glucose and FPGSVR | β, fasting glucose −0.12 (95% CI −0.14 to −0.10) |
Association of SVR with 2-h OGTT glucose and FPG
- SVR appeared more strongly associated with isolated impaired glucose tolerance than with isolated impaired fasting glucose
Mediation by HOMA-IR
- Proportion of total association explained by HOMA-IR
- 51.08%
Original publication
Higher Appendicular Skeletal Muscle Mass to Visceral Fat Area Ratio Associated With Reduced Risk of Prediabetes. Diabetes Obes Metab. Published 4 May 2026. doi:10.
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