Sarcopenic Obesity and Risk of Incident Type 2 Diabetes: A Prospective Cohort Study and Landmark Analysis From the UK Biobank
Main finding · Incident T2DResult — go to the resultHazard ratio 3.54 95% CI 3.34–3.74Authors' conclusion
SO was associated with higher T2D risk than obesity or sarcopenia alone
Study context
- Population
- Diabetes-free UK Biobank participants32,948 developed T2D
- Participants
- 479,607 participants
- Exposure
- Sarcopenic obesity vs obesity alone and sarcopenia alone
- Outcome
- Incident T2D
- Follow-up
- Median 14.2 years
Methodological detailslandmark analysis
- Landmark analysis
Main finding
As reported in the abstract
Hazard ratio
3.54
95% CI 3.34–3.74
Sarcopenic obesityvs obesity alone and sarcopenia alone
HR 3.54 (95% CI 3.34–3.74)
Observational data: associations, not effects.
Further findings
Incident T2D by phenotype transition (landmark analysis, n = 53,107): transitioning to sarcopenic obesity (SO)
| HR (95% CI) | ||
|---|---|---|
| Transitioning to SOLandmark analysis | 2.90 (2.07–4.07) | |
| 0.20.5125Hazard ratio (log scale) |
Incident T2D by phenotype transition (landmark analysis, n = 53,107): persistent SO
| HR (95% CI) | ||
|---|---|---|
| Persistent SOLandmark analysis | 3.07 (1.63–5.79) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Sarcopenic Obesity and Risk of Incident Type 2 Diabetes: A Prospective Cohort Study and Landmark Analysis From the UK Biobank. Diabetes Care. Published 13 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →