Individual and combined effects of muscle strength and visceral adiposity on incident prediabetes and type 2 diabetes in a longitudinal cohort of midlife Asian women
Authors' conclusion
Low combined muscle strength with high VAT poses a greater risk for the development of prediabetes and type 2 diabetes than high VAT alone. Muscle strengthening should be promoted alongside weight loss in diabetes prevention.
Study context
- Population
- Initially normoglycaemic midlife Asian women (mean age 56.4 years), baseline 2014–2016normoglycaemic at baseline
- Participants
- 733 women
- Exposure
- Poor combined muscle strength and/or high visceral adipose tissue (VAT) vs neither
- Outcome
- Incident prediabetes (FPG 5.6-6.9 mmol/L) or T2D (fasting glucose ≥7 mmol/L, medication use, or physician diagnosis)
- Follow-up
- 6.6 years
Methodological detailslongitudinal, modified Poisson regression
- Longitudinal
- Modified Poisson regression
Main finding
As reported in the abstract
Incident prediabetes or T2D
Adjusted relative risk (95% CI)
Poor strength + high VAThighest risk
2.63(1.81–3.82)
High VAT alone1.78-fold increased risk
1.78(1.12–2.84)
- Developed prediabetes or T2D (all participants)
- 150 (20.5%)
Observational data: associations, not effects.
Further findings
High VAT and prediabetes/T2D, stratified by muscle strength
- High VAT among women with low muscle strength, aRR
- 2.84 (1.95-4.14) (95% CI)
- High VAT among women with normal strength, aRR
- 1.66 (1.04-2.65) (95% CI)
- Stratification analyses
Original publication
Individual and combined effects of muscle strength and visceral adiposity on incident prediabetes and type 2 diabetes in a longitudinal cohort of midlife Asian women. Diabetes Obes Metab. Published 4 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →