Associations of muscle mass, strength, and quality with diabetes and the mediating role of inflammation in two National surveys from China and the United states
Authors' conclusion
Low muscle mass and muscle strength are independently or jointly associated with diabetes, and inflammation might be a potential mechanism underlying this association. Furthermore, the synergistic effects of sarcopenia and obesity could significantly increase diabetes risk.
Study context
- Population
- Adults from the 2023 China National Health Survey (CNHS; 13,420) and the 2011–2014 National Health and Nutrition Examination Survey (NHANES) (5,380); muscle mass by bioelectrical impedance analysis (BIA) (CNHS) or DXA (NHANES), strength by hand dynamometer13,420 CNHS
- Exposure
- Low muscle mass, strength, quality, sarcopenia and sarcopenia obesity vs not, for diabetes
- Outcome
- Diabetes
Methodological detailstwo national surveys (CNHS 2023, NHANES 2011-2014), multivariate logistic regression, mediation analysis
- Two national surveys (CNHS 2023, NHANES 2011-2014)
- Multivariate logistic regression
- Mediation analysis
Main finding
As reported in the abstract
Odds ratio (95 % CI)
SarcopeniaCNHS
1.93(1.64–2.27)
SarcopeniaNHANES
3.80(2.58–5.58)
Sarcopenia obesityCNHS
2.21(1.72–2.84)
Sarcopenia obesityNHANES
6.06(3.64–10.08)
Observational data: associations, not effects.
Further findings
Mediation by inflammation of associations between muscle parameters and diabetes
- Mediation proportion (partial mediation)
- 1.99 %-36.64 %, P < 0.05
Original publication
Associations of muscle mass, strength, and quality with diabetes and the mediating role of inflammation in two National surveys from China and the United states. Diabetes Res Clin Pract. Published 11 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →