Type 2 & other diabetes

Uncovering actionable cardiovascular risk subgroups in type 2 Diabetes: A latent class analysis

Diabetes Res Clin PractPublished Latent class analysis

Authors' conclusion

Diverse lifestyle and psychosocial CVD risk factor patterns impact CVD outcomes in individuals with type 2 diabetes, emphasizing the necessity of a whole-person CVD prevention tailored to the person's needs.

Study context

Population
Individuals with T2D
Comparison
Low risk vs Mobility related risk vs Psychosocial risk
Outcome
CVD risk factor classes (3-class model superior)

Main finding

As reported in the abstract

GroupValueProbability of limitations in mobilityProbability of not meeting exercise normProbability of being lonelyProbability of anxiety and depression
Low risk71.2 %
Mobility related risk19.3 %0.900.89
Psychosocial risk9.5 %0.490.56

Value

Low risk71.2 %
Mobility related risk19.3 %
Psychosocial risk9.5 %

Probability of limitations in mobility

Low risk— not stated in the abstract
Mobility related risk0.90
Psychosocial risk— not stated in the abstract

Probability of not meeting exercise norm

Low risk— not stated in the abstract
Mobility related risk0.89
Psychosocial risk— not stated in the abstract

Probability of being lonely

Low risk— not stated in the abstract
Mobility related risk— not stated in the abstract
Psychosocial risk0.49

Probability of anxiety and depression

Low risk— not stated in the abstract
Mobility related risk— not stated in the abstract
Psychosocial risk0.56

Further findings

Predictors of risk class membership

Strong predictors (OR ≥ 2.00): female gender, non-western immigrant status, lower education, financial difficulties, unfit for work and/or prior HF

Cardiovascular disease (CVD) incidence (cardiology care and/or stroke diagnosis) · 3 years

Lower in 'low risk' class vs the risk classes

Original publication

Uncovering actionable cardiovascular risk subgroups in type 2 Diabetes: A latent class analysis. Diabetes Res Clin Pract. Published 19 March 2025. doi:10.1016/j.diabres.2025.112110

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