Type 2 & other diabetes

Nutrition interventions for anxiety, depression, stress and/or diabetes‐related distress in individuals with diabetes: A systematic review and meta‐analysis of randomised controlled trials

Diabetes Obes MetabPublished Systematic review and meta-analysis of randomised controlled trials

Authors' conclusion

This review provides evidence that nutrition interventions, particularly supplement use or altered macronutrient composition, improve depression and anxiety for those with T2D. Future research should evaluate the impact of whole dietary patterns on mental health in adults with diabetes, especially T1D, to inform effective food-based nutrition advice, rather than focusing on individual supplements.

Study context

Population
Adults (≥18 years) with T1D or T2D; all publications included adults with T2D, one both T1D and T2D30 publications
Comparison
Nutrition interventions vs control
Outcome
Depression, anxiety, stress and/or diabetes distress outcomes
Methodological detailsrandom effects meta-analyses
  • Random effects meta-analyses

Pooled result

As reported in the abstract

Mental health outcomes (random-effects meta-analyses)
WMD (95% CI)
Nutrition supplementationvs ControlDepression (BDI)
−3.13(−5.09 to −1.17)
Nutrition supplementationvs ControlAnxiety (Beck Anxiety Inventory)
−1.30(−2.08 to −0.52)
Altering macronutrient compositionDiabetes-related distress (PAID); significantly lowered
−4.20(−8.18 to −0.22)

Original publication

Nutrition interventions for anxiety, depression, stress and/or diabetes‐related distress in individuals with diabetes: A systematic review and meta‐analysis of randomised controlled trials. Diabetes Obes Metab. Published 26 January 2026. doi:10.1111/dom.70444

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