Type 2 & other diabetes

The role of depression and diabetes distress in glycemic control: A meta-analysis

Diabetes Res Clin PractPublished Systematic review and meta-analysis

Authors' conclusion

Depression and diabetes distress are associated with poorer glycemic control and reduced self-care behaviours. Findings highlight the need for standardized measures and longitudinal studies to explore mechanisms underlying these associations.

Study context

Population
Individuals with diabetes; studies conducted 2001–2024
Participants
19,537 individuals61 studies
Outcome
Associations of depression and diabetes distress with glycemic control (HbA1c) and self-care behaviours
Methodological detailsrandom-effects models, subgroup analyses by diabetes type, geographic location and measurement tools
  • Random-effects models
  • Subgroup analyses by diabetes type, geographic location and measurement tools

Pooled result

As reported in the abstract

Association of depression and diabetes distress with poorer glycemic control and reduced self-care

Correlation with poorer glycemic control (95% CI 0.15 to 0.31; p < 0.001)

r = 0.23

Correlation with self-care behaviours (95% CI −0.28 to −0.10; p < 0.001)

r = −0.19

Further pooled results

Subgroups: diabetes type and geographic location

Mixed diabetes populations (95% CI 0.30 to 0.40; I2 = 0 %)
r = 0.35
Studies in Europe
r = 0.28
Studies in North America
r = 0.34

Original publication

The role of depression and diabetes distress in glycemic control: A meta-analysis. Diabetes Res Clin Pract. Published 30 January 2025. doi:10.1016/j.diabres.2025.112014

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