Type 2 diabetes outcomes in patients with Posttraumatic stress disorder and psychiatric comorbidity
Authors' conclusion
More psychiatric comorbidity in patients with PTSD is associated with worse glycemic control, increased risk for T2D micro- and macro- complications, and mortality. Research is needed to determine if treatment and improvement in patients with comorbid psychiatric disorders leads to improved T2D outcomes.
Study context
- Population
- Veterans Health Administration (VHA) patients with comorbid posttraumatic stress disorder (PTSD) and T2D, adequate HbA1c control, not on insulin, free of microvascular and macrovascular complications at index; 64.4% ≥60 years, 90.9% male, 69.1% White
- Participants
- 152,171 patients
- Exposure
- PTSD comorbidity classes: high comorbidity and depression + anxiety vs low comorbidity
- Outcome
- All-cause mortality
Methodological detailslatent class analysis
- Latent class analysis
Main finding
As reported in the abstract
Each group vs low comorbidityHazard ratio (95% CI)
High comorbidity
1.39(1.28–1.50)
Depression + anxiety
1.18(1.14–1.23)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Worse glycemic controlDepression + anxietyvs Low comorbidity | 1.04 (1.02–1.06) | |
| Microvascular complicationsDepression + anxietyvs Low comorbidity | 1.04 (1.02–1.06) | |
| 0.512Hazard ratio (log scale) |
Original publication
Type 2 diabetes outcomes in patients with Posttraumatic stress disorder and psychiatric comorbidity. Diabetes Res Clin Pract. Published 14 April 2026. doi:10.
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