Influence of diabetes mellitus on the pathological profile of aortic stenosis: a sex-based approach
Authors' conclusion
DM produces sex-specific pathological phenotypes in AV of AS patients. Importantly, women with diabetes are more prone to develop AV calcification. DM should be considered as a risk factor in AS especially in women.
Study context
- Population
- Patients with severe aortic stenosis (AS) undergoing surgical valve replacement (27.6% diabetes mellitus (DM), 59.4% men)
- Participants
- 283 patients
- Comparison
- AS patients with vs without DM, by sex
- Outcome
- Pathological markers in AVs and VICs by sex and DM
Methodological detailssex-based analysis, in vitro experiments in valve interstitial cells (VICs), In vitro VICs exposed to high glucose (25 mM) for 24, 48 and 72 h
- Sex-based analysis
- In vitro experiments in VICs
- In vitro VICs exposed to high glucose (25 mM) for 24, 48 and 72 h
Main finding
As reported in the abstract
- Oxidative stress and metabolic dysfunction markers increased in aortic valve (AVs) from diabetic vs non-diabetic AS patients in both sexes
- Disbalanced oxidative stress and enhanced inflammation more predominant in AVs from male diabetic AS patients
- Osteogenic markers increased exclusively in AVs of diabetic women
- Oxidative stress, inflammation, calcification and metabolic alteration profiles increased in diabetic VICs, with sex-specific differences
- VICs in hyperglycemic-like conditions: inflammatory responses in men; rapid and higher production of pro-osteogenic molecules in women
Original publication
Influence of diabetes mellitus on the pathological profile of aortic stenosis: a sex-based approach. Cardiovasc Diabetol. Published 17 October 2023. doi:10.
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