Myocardial transcriptomic analysis of diabetic patients with aortic stenosis: key role for mitochondrial calcium signaling
Authors' conclusion
Our data support a crucial role for mitochondrial Ca2+ signaling in T2D-induced cardiac dysfunction in severe AS patients, from a structural reticulum-mitochondria Ca2+ uncoupling to a mitochondrial gene remodeling. Thus, our findings open a new therapeutic avenue to be tested in animal models and further human cardiac biopsies in order to propose new treatments for T2D patients suffering from AS.
Study context
- Population
- Patients with severe aortic stenosis, preserved ejection fraction and no additional heart disease, referred for valve replacement
- Participants
- 34 vs 50
- Comparison
- T2D vs no T2D in severe aortic stenosis
- T2Dn = 34
- Non-diabeticsn = 50reference
- Outcome
- Myocardial transcriptomic and histological alterations
Methodological detailstranscriptomic and histological analyses of intra-operative myocardial left ventricular (LV) biopsy
- Transcriptomic and histological analyses of intra-operative myocardial LV biopsy
Main finding
As reported in the abstract
- Significantly differentially expressed genes (RNAseq)
- 1029
Further findings
Clinical and echocardiographic phenotype
- T2D had similar aortic stenosis (AS) severity but worse cardiac remodeling, systolic and diastolic function than non-diabetics
Original publication
Myocardial transcriptomic analysis of diabetic patients with aortic stenosis: key role for mitochondrial calcium signaling. Cardiovasc Diabetol. Published 8 July 2024. doi:10.
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