Incidence and associates of aortic valve replacement in people with or without type 2 diabetes: The Fremantle diabetes study phase II
Authors' conclusion
Type 2 diabetes more than doubles the risk of AVR after adjusting for the competing risk of death. People with Type 2 diabetes going on to require AVR were more intensively managed and were more likely to have DSPN at baseline.
Study context
- Population
- FDS2 participants with T2D (mean age 66 years, 53% males) and matched people without diabetes, followed from entry (2008–2011) to end-2021matched cohort
- Participants
- 1,430 vs 5,720
- Exposure
- T2D vs no diabetes
- Type 2 diabetesn = 1,430
- Without diabetesn = 5,720reference
- Outcome
- Incident AVR, ascertained from validated linked databases
- Follow-up
- Entry (2008-2011) to end-2021
Methodological detailscommunity-based, age-, sex- and postcode-matched controls, validated linked databases, competing risk models
- Community-based
- Age-, sex- and postcode-matched controls
- Validated linked databases
- Competing risk models
Main finding
As reported in the abstract
First incident AVR hospitalisation · 73,498 person-years of follow-up
Type 2 diabetes vs Without diabetesEstimate (95% CI)P value
First incident AVR hospitalisation
IRR 2.40(1.38–4.08)
P = 0.0007Pooled analysis
csHR 2.38(1.43–3.96)
Pooled analysis; competing risk model
sdHR 2.34(1.41–3.88)
Observational data: associations, not effects.
Further findings
Prior AVR at baseline
P = 0.589
Associates of incident aortic valve replacement (AVR) within T2D
- Bivariable association with baseline glucose-lowering treatment intensity
- P = 0.003
- Association with distal symmetrical polyneuropathy (DSPN) after age and sex adjustment
- P = 0.025
Original publication
Incidence and associates of aortic valve replacement in people with or without type 2 diabetes: The Fremantle diabetes study phase II. Diabet Med. Published 5 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →