Temporal trends in chronic complications of diabetes by sex in community-based people with type 2 diabetes: the Fremantle Diabetes Study
Authors' conclusion
The incidence of chronic complications in Australians with type 2 diabetes and without diabetes has fallen similarly in both sexes over recent decades, consistent with comparably improved overall CVD risk factor management.
Study context
- Population
- Community-based male and female Australian adults with T2D or without known diabetes; mean age 64.0 (FDS1) and 65.4 (FDS2) years; 48.7% and 51.8% males
- Participants
- 1,291 / 1,509 / 5,159 / 6,036
- Exposure
- FDS2 vs FDS1, by sex, in T2D and without diabetes
- FDS1 T2Dn = 1,291reference
- FDS2 T2Dn = 1,509
- FDS1 without diabetesn = 5,159reference
- FDS2 without diabetesn = 6,036
- Outcome
- Five-year incidence rates of first MI, stroke, HF hospitalization, lower extremity amputation, cardiovascular disease (CVD) death and all-cause mortality; IRRs males vs females
- Follow-up
- 5 years
Methodological detailscommunity-based, two phases (FDS1 recruited 1993-1996; FDS2 recruited 2008-2011), age-, sex- and postcode-matched individuals without diabetes
- Community-based
- Two phases (FDS1 recruited 1993-1996; FDS2 recruited 2008-2011)
- Age-, sex- and postcode-matched individuals without diabetes
Main finding
As reported in the abstract
5-year IRRs (FDS2 vs FDS1) for first MI, stroke, HF hospitalization, lower extremity amputation, CVD death and all-cause mortality, by sex
T2D: IR ratios (IRRs) for all endpoints lower in FDS2 than FDS1 for both sexes
11-62% lower
Without diabetes: IRRs lower in FDS2 vs FDS1, apart from stroke in females
8-56% lower
Without diabetes, stroke in females: non-significantly higher in FDS2 vs FDS1
41% higher
Observational data: associations, not effects.
Further findings
Risk factors in T2D, FDS1 to FDS2
- Greater improvements in smoking rates in males offset by greater reduction in systolic blood pressure in females
Original publication
Temporal trends in chronic complications of diabetes by sex in community-based people with type 2 diabetes: the Fremantle Diabetes Study. Cardiovasc Diabetol. Published 16 September 2023. doi:10.
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