The triglyceride-glucose index is a predictor for cardiovascular and all-cause mortality in cardiovascular disease (CVD) patients with diabetes or pre-diabetes: evidence from NHANES 2001–2018
Authors' conclusion
A U-shaped association was observed between the baseline TyG index with CVD and all-cause mortality in CVD patients with diabetes or pre-diabetes in a American population. The thresholds of 8.84 and 9.05 for CVD and all-cause mortality, respectively.
Study context
- Population
- American adults with CVD and diabetes or pre-diabetes, NHANES 2001–2018
- Participants
- 1,072 adults
- Exposure
- Baseline triglyceride-glucose (TyG) index below vs above threshold values
- Outcome
- All-cause and cardiovascular (CV) mortality
- Follow-up
- Up to December 31, 2019
Methodological detailsNHANES 2001–2018, linked to National Death Index, multivariate Cox proportional hazards models, restricted cubic splines, two-piecewise Cox model
- NHANES 2001–2018
- Linked to National Death Index
- Multivariate Cox proportional hazards models
- Restricted cubic splines
- Two-piecewise Cox model
Main finding
As reported in the abstract
7541 person-years of follow-up
- All-cause deaths
- 461
- CVD-related deaths
- 154
- All-cause mortality, TyG index < 9.05: HR
- 0.47 (0.27-0.81) (95% CI)
- CVD mortality, TyG index < 8.84: HR
- 0.25 (0.07-0.89) (95% CI)
- All-cause mortality, TyG index > 9.05: HR
- 1.42 (1.02-1.99) (95% CI)
- CVD mortality, TyG index > 8.84: HR
- 1.77 (1.08-2.91) (95% CI)
Observational data: associations, not effects.
Original publication
The triglyceride-glucose index is a predictor for cardiovascular and all-cause mortality in CVD patients with diabetes or pre-diabetes: evidence from NHANES 2001–2018. Cardiovasc Diabetol. Published 17 October 2023. doi:10.
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