Association between the triglyceride–glucose index and all-cause and cardiovascular disease (CVD) mortality in the young population with diabetes
Authors' conclusion
Our results suggest a U-shaped association between TyG index and all-cause and CVD mortality among young patients with diabetes in the United States, with threshold values of 9.18 and 9.16 for CVD and all-cause mortality, respectively.
Study context
- Population
- Young patients with diabetes in the US, National Health and Nutrition Examination Survey (NHANES) 2001–2018
- Participants
- 2,440 patients
- Exposure
- Triglyceride-glucose (TyG) index above vs below threshold
- Outcome
- All-cause and CVD mortality
- Follow-up
- Median 8.2 years
Methodological detailsNHANES 2001-2018, linked to National Death Index, restricted cubic splines, two-segment Cox proportional risk model
- NHANES 2001-2018
- Linked to National Death Index
- Restricted cubic splines
- Two-segment Cox proportional risk model
Main finding
As reported in the abstract
- Deaths from all causes
- 332
- Deaths from CVD
- 82
- U-shaped association; threshold for all-cause mortality
- 9.18
- U-shaped association; threshold for CVD mortality
- 9.16
- TyG index ≥9.18: all-cause mortality, HR
- 1.77 (95% CI 1.05-2.96)
- TyG index ≥9.16: CVD mortality, HR
- 2.38 (95% CI 1.05-5.38)
Observational data: associations, not effects.
Original publication
Association between the triglyceride–glucose index and all-cause and CVD mortality in the young population with diabetes. Cardiovasc Diabetol. Published 16 May 2024. doi:10.
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