The association between triglyceride-glucose index and all-cause/cardiovascular mortality in patients with different glucose metabolism statuses
Authors' conclusion
TyG was associated with an increased risk of all-cause and cardiovascular death in the normoglycemic subgroup, but not in the dysglycemic subgroup. In the diabetes subgroup, the association between the TyG and mortality was nonlinear. The predictive value of TyG across different glucose metabolism statuses provides new evidence for medical practice.
Study context
- Population
- National Health and Nutrition Examination Survey (NHANES) participants (nine cycles) categorized by glucose metabolism status: normoglycemia, dysglycemia, DM
- Exposure
- TyG index across glucose metabolism statuses
- Outcome
- All-cause and cardiovascular mortality
- Follow-up
- Median 9.2 years
Methodological detailsNHANES, nine cycles
- NHANES, nine cycles
Main finding
As reported in the abstract
normoglycemicHazard ratio (95% CI)
All-cause mortality; per standard unit increase in TyG; 35% higher risk
1.35(1.17–1.56)
CV mortality; per standard unit increase in TyG; 38% higher risk
1.38(1.04–1.84)
Per standard unit increase in TyG, as printed
- Diabetes: U-shaped association between TyG and all-cause/CV mortality (RCS), inflection point
- 9.1
Observational data: associations, not effects.
Further findings
Prediction of 3-year mortality: TyG vs atherogenic index of plasma (AIP) (time-dependent ROC)
- TyG superior to AIP for 3-year mortality prediction in normoglycemic and diabetic individuals
Subgroup analyses (age, sex, blood pressure)
- Significant interaction effects of age and sex on TyG–mortality association
Original publication
The association between triglyceride-glucose index and all-cause/cardiovascular mortality in patients with different glucose metabolism statuses. Cardiovasc Diabetol. Published 24 September 2025. doi:10.
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