Association between Triglyceride-Glucose indices and ischemic stroke risk across different glucose metabolism statuses
Authors' conclusion
TyG-related indices, particularly TyG-BMI and TyG-WC, are effective in predicting the risk of ischemic stroke, especially among individuals with prediabetes and normal glucose levels. These findings underscore the utility of TyG indices as tools for early detection and preventive strategies in stroke risk management across various states of glucose metabolism.
Study context
- Population
- UK Biobank participants free from ischemic stroke at baseline, categorized by glucose metabolism status
- Participants
- 392,733 participants
- Exposure
- Higher vs lower triglyceride-glucose (TyG)-related indices across glucose metabolism statuses
- Outcome
- Incident ischemic stroke
- Follow-up
- Median 14.68 years
Methodological detailsUK Biobank, Cox proportional hazards models adjusted for demographic and clinical covariates
- UK Biobank
- Cox proportional hazards models adjusted for demographic and clinical covariates
Main finding
As reported in the abstract
Ischemic stroke · median 14.68 years
Participants with ischemic stroke
8033
Observational data: associations, not effects.
Original publication
Association between Triglyceride-Glucose indices and ischemic stroke risk across different glucose metabolism statuses. Diabetes Res Clin Pract. Published 24 February 2025. doi:10.
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