Dietary potassium intake and its interaction with sodium intake on risk of developing cardiovascular disease in persons with type 2 diabetes: The Japan Diabetes Complication and its Prevention Prospective study ( JDCP study 12)
Authors' conclusion
Low potassium intake in conjunction with high sodium intake was significantly associated with increased incident CVD in persons with T2DM. However, CVD incidence was not related to high potassium intake, regardless of sodium intake.
Study context
- Population
- Japanese persons with T2D, 40–75 years of age, who completed a brief-type self-administered Diet History Questionnaire at baseline (JDCP study, begun 2007)analysed
- Participants
- 1,477 persons
- Exposure
- Daily potassium intake tertiles
- Outcome
- CVD event
- Follow-up
- Median 7 years (3.9-8.1 years)
Methodological detailsnationwide, Cox regression adjusted for confounders
- Nationwide
- Cox regression adjusted for confounders
Main finding
As reported in the abstract
Incident CVD by potassium intake tertile
- Significant associations were not shown between potassium intake and incidence of cardiovascular disease (CVD)
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| CVD stratified by potassium and sodium intake tertiles (reference: bottom tertile of each)Bottom potassium tertile + second sodium tertilevs Reference | 2.79 (1.02–7.63) | |
| CVD stratified by potassium and sodium intake tertiles (reference: bottom tertile of each)Bottom potassium tertile + top sodium tertilevs Reference | 3.92 (1.30–11.79) | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Dietary potassium intake and its interaction with sodium intake on risk of developing cardiovascular disease in persons with type 2 diabetes: The Japan Diabetes Complication and its Prevention Prospective study ( JDCP study 12). Diabetes Obes Metab. Published 28 October 2024. doi:10.
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