Autonomic nervous system responses to hypo- and hyperglycemia in type 2 diabetes and prediabetes
Authors' conclusion
Alterations in glucose-dependent responses of counter-regulatory hormones and the ANS appear before, and probably contribute to, the onset of T2D. Together with other reported alterations in neuroendocrine pathways, the findings suggest that a maladaptation of the brain's responses to glucose fluctuations is important in T2D progression.
Study context
- Population
- Individuals with T2D, prediabetes or normoglycemia undergoing a stepwise hyperinsulinemic-euglycemic-hypoglycemic clamp and a hyperglycemic clamp
- Participants
- 19 / 18 / 17
- Exposure
- T2D vs prediabetes (PD) vs normoglycemia (NG)
- T2Dn = 19
- PDn = 18
- NGn = 17reference
- Outcome
- Glucose-dependent responses of catecholamines and autonomic nervous system (ANS) activity (symptoms, HRV, hemodynamics)
Main finding
As reported in the abstract
- Hypoglycemic adrenaline response strongly associated with insulin resistance (M-value)
- P < .05
- Insulin resistance associated with attenuated heart rate and heart rate variability (HRV) (PLF, PHF) responses at glucose plateau 2.7 mmol/L, independent of BMI and HbA1c
- P < .05
Observational data: associations, not effects.
Original publication
Autonomic nervous system responses to hypo- and hyperglycemia in type 2 diabetes and prediabetes. Eur J Endocrinol. Published 26 October 2024. doi:10.
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