Effect of Hypoglycemia on QT Interval in Individuals With and Without Type 2 Diabetes: A Randomized Crossover Trial
Authors' conclusion
Hypoglycemia prolonged QTc in healthy participants, and this was not altered by MR blockade. In individuals with type 2 diabetes, 2 hypoglycemic episodes were required to achieve prolongation. Reassuringly, in both study populations, hypoglycemia-induced QTc prolongation resolved quickly with no apparent residual effects the next day.
Study context
- Population
- Healthy individuals (crossover, 3 conditions) and individuals with T2D (hypoglycemia only)27 healthy, 16 T2D
- Comparison
- Hypoglycemia vs euglycemia vs hypoglycemia with mineralocorticoid receptor (MR) blockade pretreatment
- T2D hypoglycemian = 16
- Primary endpoint
- QTc interval
Methodological detailsdouble-blinded, hyperinsulinemic clamps
- Double-blinded
- Hyperinsulinemic clamps
Primary result
As reported in the abstract
QTc in healthy participants · during morning and afternoon clamps
- MR blockade did not alter the response to hypoglycemia
- Hypoglycemia vs Euglycemia: P < 0.0001
Further findings
QTc in T2D, afternoon hypoglycemia vs morning baseline
- Significant QTc prolongation during afternoon hypoglycemia only
- 461.96 ± 49.14 vs 428.90 ± 28.54, P < .05
QTc recovery · 90 minutes after return to euglycemia and following day
- QTc similar to baseline in both populations
Original publication
Effect of Hypoglycemia on QT Interval in Individuals With and Without Type 2 Diabetes: A Randomized Crossover Trial. J Clin Endocrinol Metab. Published 9 January 2025. doi:10.
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