Effect of exercise training on insulin-stimulated glucose disposal: a systematic review and meta-analysis of randomized controlled trials
Pooled result · Insulin-stimulated glucose disposalResult — go to the resultSMD 0.52 95% CI 0.39–0.65Authors' conclusion
Exercise training for at least four weeks significantly increases insulin-stimulated glucose disposal. Weight loss maximizes the effect and may be needed to improve hepatic insulin sensitivity. Differences in tracer methodology contribute to divergent outcomes and should be considered when assessing conclusions from research examining the effect of exercise on insulin action.
Study context
- Population
- Adults in RCTs lasting ≥4 weeks with insulin-stimulated glucose disposal measured by hyperinsulinemic euglycemic clamp; MEDLINE, EMBASE, CENTRAL searched until January 202136 interventions
- Participants
- 851 adults25 trials
- Comparison
- Exercise training vs control
- Outcome
- Insulin-stimulated glucose disposal
Methodological detailsmeta-regression, PEDro rating indicated relatively low risk of bias (5.8 ± 0.22)
- Meta-regression
- PEDro rating indicated relatively low risk of bias (5.8 ± 0.22)
Pooled result
As reported in the abstract
SMD
0.52
95% CI 0.39–0.65
P < 0.001
Exercisevs Control
SMD 0.52 (95% CI 0.39–0.65); P < 0.001
Further pooled results
| Outcome | SMD (95% CI) | P value | |
|---|---|---|---|
| Glucose disposal, trials without isotopic tracersI2 = 55% | 0.63 (0.48–0.77) | P < 0.001 | |
| Glucose disposal, trials with tracers added to exogenous clamp glucoseI2 = 0% | 0.34 (0.03–0.66) | P = 0.034 | |
| −0.500.51Difference (linear scale) |
Meta-regression of between-trial heterogeneity
- Only percent weight change explained heterogeneity, β
- 0.069 (95% CI 0.005, 0.013)
- Model included aerobic exercise, weight change and tracer technique
Original publication
Effect of exercise training on insulin-stimulated glucose disposal: a systematic review and meta-analysis of randomized controlled trials. Int J Obes (Lond). Published 24 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →