Relationship of Plasma Apolipoprotein C-I Truncation With Risk of Diabetes in the Multi-Ethnic Study of Atherosclerosis and the Actos Now for the Prevention of Diabetes Study
Authors' conclusion
Our results indicate that apoC-I truncation may contribute to changes in glucose levels, IR, and risk of diabetes.
Study context
- Population
- Nondiabetic participants in Multi-Ethnic Study of Atherosclerosis (MESA) and participants with prediabetes in ACT NOW4,742 MESA · Nondiabetic participants in MESA 4,742 · participants with prediabetes in ACT NOW 524
- Exposure
- Higher vs lower truncated-to-native apoC-I proteoform ratio, per SD
- Outcome
- Incident diabetes (FPG ≥7.0 mmol/L or hypoglycemic medication use in MESA; FPG ≥7.0 mmol/L or 2-h glucose ≥11.1 mmol/L on OGTT in ACT NOW)
Methodological detailstwo cohorts: MESA and ACT NOW, mass spectrometry immunoassay
- Two cohorts: MESA and ACT NOW
- Mass spectrometry immunoassay
Main finding
As reported in the abstract
Incident diabetes per SD higher C-I'/C-I
MESA: HR per SD (564 events; median follow-up 9 years)
0.87
95% CI 0.79, 0.95P = 0.0036
ACT NOW: per SD (59 events; median follow-up 2.5 years)
0.66
95% CI 0.48, 0.91P = 0.004
Observational data: associations, not effects.
Secondary outcomes
MESA: change in FPG and HOMA-IR with higher C-I'/C-I
- FPG (smaller increase)
- −0.5%; P < 0.0001
- HOMA-IR (smaller increase)
- −2.9%; P = 0.011
- Follow-up adjusted for baseline
MESA: total apoC-I concentrations
- Not associated with changes in FPG, HOMA-IR or incident diabetes
ACT NOW: change in OGTT AUCglucose and Matsuda insulin sensitivity index (ISI) with higher C-I'/C-I
- AUCglucose (smaller increase)
- −1.8%; P = 0.0052
- ISI (greater increase)
- 7.2%; P = 0.0095
Original publication
Relationship of Plasma Apolipoprotein C-I Truncation With Risk of Diabetes in the Multi-Ethnic Study of Atherosclerosis and the Actos Now for the Prevention of Diabetes Study. Diabetes Care. Published 25 October 2024. doi:10.
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