Type 2 & other diabetes

Associations of a proinflammatory diet, habitual salt intake, and the onset of type 2 diabetes: A prospective cohort study from the UK Biobank

Diabetes Obes MetabPublished Prospective cohort study

Authors' conclusion

Our findings indicate that a proinflammatory diet and higher habitual salt intake were associated with an increased risk of type 2 diabetes. These results support the public health promotion of an anti-inflammatory diet and reducing salt intake to prevent the onset of type 2 diabetes.

Study context

Population
UK Biobank participants who completed at least one 24-h dietary questionnaire and were free of diabetes at baseline
Participants
171,094 participants
Exposure
High vs low E-DII; habitual salt intake
Outcome
Incident T2D (from linked medical records)
Follow-up
Median 13.5 years
Methodological detailsUK Biobank, Cox proportional hazard regression, Habitual salt intake from self-reported frequency of adding salt to foods; E-DII from 28 food parameters
  • UK Biobank
  • Cox proportional hazard regression
  • Habitual salt intake from self-reported frequency of adding salt to foods; E-DII from 28 food parameters

Main finding

As reported in the abstract

Incident T2D

High vs low E-DII: heightened risk of developing T2D

18%

T2D cases documented

6216

Observational data: associations, not effects.

Further findings

Incident T2D: proinflammatory diet and always adding salt to foods (highest risk)

HR (95% CI)
Proinflammatory diet + always adding salt1.60 (1.32–1.94)

Original publication

Associations of a proinflammatory diet, habitual salt intake, and the onset of type 2 diabetes: A prospective cohort study from the UK Biobank. Diabetes Obes Metab. Published 26 February 2024. doi:10.1111/dom.15517

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