Associations of a proinflammatory diet, habitual salt intake, and the onset of type 2 diabetes: A prospective cohort study from the UK Biobank
Authors' conclusion
Our findings indicate that a proinflammatory diet and higher habitual salt intake were associated with an increased risk of type 2 diabetes. These results support the public health promotion of an anti-inflammatory diet and reducing salt intake to prevent the onset of type 2 diabetes.
Study context
- Population
- UK Biobank participants who completed at least one 24-h dietary questionnaire and were free of diabetes at baseline
- Participants
- 171,094 participants
- Exposure
- High vs low E-DII; habitual salt intake
- Outcome
- Incident T2D (from linked medical records)
- Follow-up
- Median 13.5 years
Methodological detailsUK Biobank, Cox proportional hazard regression, Habitual salt intake from self-reported frequency of adding salt to foods; E-DII from 28 food parameters
- UK Biobank
- Cox proportional hazard regression
- Habitual salt intake from self-reported frequency of adding salt to foods; E-DII from 28 food parameters
Main finding
As reported in the abstract
Incident T2D
High vs low E-DII: heightened risk of developing T2D
18%
T2D cases documented
6216
Observational data: associations, not effects.
Further findings
Incident T2D: proinflammatory diet and always adding salt to foods (highest risk)
| HR (95% CI) | ||
|---|---|---|
| Proinflammatory diet + always adding salt | 1.60 (1.32–1.94) | |
| 0.512Hazard ratio (log scale) |
Original publication
Associations of a proinflammatory diet, habitual salt intake, and the onset of type 2 diabetes: A prospective cohort study from the UK Biobank. Diabetes Obes Metab. Published 26 February 2024. doi:10. 1111/ dom. 15517
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