Relationship between severe hypoglycemia or impaired awareness of hypoglycemia and diabetes-related health status, global cognition and executive functions in adults with type 1 diabetes without severe anxiety or depression
An erratum to this article was published (Diabetes Res Clin Pract, Aug 2026 ↗)
Authors' conclusion
In our cohort, executive dysfunction in T1D was not associated with SH or IAH. IAH was associated with PD, and both SH and IAH were related to behavioral dysfunction.
Study context
- Population
- Adults with T1D attending a tertiary diabetes service, excluding those screening positive for severe anxiety or depression
- Participants
- 165 adults
- Exposure
- Severe hypoglycemia (SH) or impaired awareness of hypoglycemia (IAH) vs no SH or IAH
- Outcome
- Prevalence of SH and IAH
Methodological detailssingle tertiary diabetes service
- Single tertiary diabetes service
Main finding
As reported in the abstract
Prevalence of SH
35%
Prevalence of IAH by Minimally Modified Clarke Hypoglycemia Survey (MMCHS) full-scale
13%
Prevalence of IAH by MMCHS factor 1
28%
Observational data: associations, not effects.
Further findings
Psychological distress (PD) score
- Higher PD scores with IAH by factor 1
- P = 0.008
Barriers to activity (BA) score
- Higher BA scores with SH and IAH (full-scale or factor 1)
- all p < 0.05
Global cognition and executive functions (EF)
- No impairment of global cognition or EF with SH or IAH
Z-score IFS vs non-diabetic individuals
- Participant Z-score IFS lower than in non-diabetic individuals
- P < 0.001
Original publication
Relationship between severe hypoglycemia or impaired awareness of hypoglycemia and diabetes-related health status, global cognition and executive functions in adults with type 1 diabetes without severe anxiety or depression. Diabetes Res Clin Pract. Published 11 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →