Impaired Awareness of Hypoglycemia in Older Adults With Type 1 Diabetes: A Post Hoc Analysis of the WISDM Study
Authors' conclusion
In older adults with type 1 diabetes, longer diabetes duration and greater daytime hypoglycemia are drivers of IAH. Dedicated research can personalize IAH management.
Study context
- Population
- Adults ≥60 years old with T1D in the WISDM study; age 68.1 ± 5.7 years, 52% female
- Participants
- 199 adults
- Comparison
- Impaired awareness of hypoglycemia (IAH) vs normal awareness of hypoglycemia (NAH)
- Primary endpoint
- Clinical and glycemic correlates of IAH
- Follow-up
- Baseline
Methodological detailsmultiple logistic regression variable selection
- Multiple logistic regression variable selection
Primary result
As reported in the abstract
Factors associated with IAH (logistic regression)
Odds ratio (95% CI)P value
Longer diabetes duration
1.03(1.01–1.05)
P = 0.008Greater daytime hypoglycemia
1.31(1.15–1.51)
P < 0.0001- Prevalence of IAH
- 30.6%
Further findings
Predictors of restored awareness · 26 weeks
| Estimate | P value | ||
|---|---|---|---|
| Daytime hypoglycemiaLess daytime hypoglycemia predicted restored awareness | OR per additional percentage point 0.55 (95% CI 0.32–0.94) | P = 0.029 | |
| Diabetes duration | OR per additional year 0.96 (95% CI 0.91–1.004) | P = 0.07 | |
| 0.20.5125Ratio (log scale) |
Original publication
Impaired Awareness of Hypoglycemia in Older Adults With Type 1 Diabetes: A Post Hoc Analysis of the WISDM Study. Diabetes Care. Published 7 May 2024. doi:10.
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