Reduced Prevalence of Impaired Awareness of Hypoglycemia Over Two Decades in Population-Based Samples of Youth With Type 1 Diabetes
Authors' conclusion
IAH and SH have declined substantially over two decades, reflecting improved diabetes care.
Study context
- Population
- Youth (12–18 years old) with T1D, population-based samples
- Exposure
- Impaired awareness of hypoglycemia (IAH) and severe hypoglycemia (SH) prevalence in 2024 vs 2015 vs 2002 cohorts
- Outcome
- Prevalence of IAH (Modified Clarke questionnaire)
Methodological detailspopulation-based, three cohorts (2002, 2015, 2024)
- Population-based
- Three cohorts (2002, 2015, 2024)
Main finding
As reported in the abstract
IAH prevalence
2024 vs 2002: P < 0.001 · 2024 vs 2015: P = 0.051
Observational data: associations, not effects.
Further findings
| Outcome | 2024 | Estimate |
|---|---|---|
| SH rate2015 vs 2024 | 0.92 per 100 patient-years | fold higher (2024 3.5-fold lower) 3.5 (95% CI 1.2–12.5) |
| SH rate2002 vs 2024 | fold higher (2024 30-fold lower) 30 (95% CI 12.7–98.9) |
HbA1c across cohorts
- HbA1c reduction across cohorts
- P < 0.001
Continuous glucose monitoring (CGM) hypoglycemia exposure, IAH vs non-IAH (2024)
- Hypoglycemia exposure did not differ between IAH and non-IAH on CGM metrics
- P > 0.05
Original publication
Reduced Prevalence of Impaired Awareness of Hypoglycemia Over Two Decades in Population-Based Samples of Youth With Type 1 Diabetes. Diabetes Care. Published 15 May 2026. doi:10.
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