Evaluating the impact of severe hypoglycaemia definition wording on severe hypoglycaemia history assessment
Authors' conclusion
This U.S. national survey with individuals living with type 1 diabetes demonstrated significant discrepancies in SH history when assessed with different SH definition wordings. Race and socioeconomic status were associated with these discrepancies.
Study context
- Population
- Registrants of the T1D Exchange, a US national T1D patient registry; 52% female, mean age 46 ± 15 years, 95% White, mean diabetes duration 25 ± 16 years
- Participants
- 1,580 valid responses
- Exposure
- Different severe hypoglycaemia (SH) definition wordings for 6-month SH history assessment
- Outcome
- SH history assessment (prevalence of SH and number of SH episodes) by SH definition wording
- Follow-up
- 6 months
Methodological detailsnational survey, T1D Exchange registry
- National survey
- T1D Exchange registry
Main finding
As reported in the abstract
Prevalence of SH and number of SH episodes
- Four SH definition wordings yielded significant variations in SH prevalence and number of SH episodes
- ADA/ENDO 2013 wording yielded the highest results on both metrics; HypoA-Q and ADA 2023 yielded the lowest
Observational data: associations, not effects.
Further findings
Correlation of number of SH episodes across wordings, in participants reporting ≥1 SH episode
- Poor correlation (Rs)
- 0.09-0.37; p < 0.001
Factors associated with discrepancies in SH history
- Race, education level and household income associated with higher odds of discrepancies
- P < 0.05
Original publication
Evaluating the impact of severe hypoglycaemia definition wording on severe hypoglycaemia history assessment. Diabet Med. Published 11 January 2025. doi:10.
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