Relation of Insulin Resistance to Brain Glucose Metabolism in Fasting and Hyperinsulinemic States: A Systematic Review and Meta-analysis
Authors' conclusion
Metabolic conditions modify associations between insulin resistance and brain glucose metabolism; ie, most individuals with insulin resistance display hypometabolism during fasting and hypermetabolism during insulin stimulation.
Study context
- Population
- Studies assessing brain glucose metabolism (uptake or metabolic rate) by 18F-2-fluoro-2-deoxy-D-glucose-PET in individuals with measures of or clinical proxies for insulin resistance; PubMed, Embase, Cochrane Library, Web of Science to February 202231 studies
- Comparison
- Insulin resistance vs no insulin resistance, brain glucose metabolism in fasting vs insulin-stimulated states
- Outcome
- Brain glucose metabolism (SMD, Hedge's g) by metabolic condition (fasting vs insulin stimulation)
Methodological detailsrandom-effects models, Hedge's g SMD, two independent investigators extracted data and assessed study quality, 2 independent investigators extracted data and assessed study quality
- Random-effects models
- Hedge's g SMD
- Two independent investigators extracted data and assessed study quality
- 2 independent investigators extracted data and assessed study quality
Pooled result
As reported in the abstract
Brain glucose metabolism
Fasting: insulin resistance associated with decreased brain glucose metabolism
−0.47 SD
SMD; 95% CI −0.73 to −0.22; P < .001; I2 = 71%
Insulin stimulation: insulin resistance associated with increased brain glucose metabolism
1.44 SD
SMD; 95% CI 0.79 to 2.09; P = .002; I2 = 43%
Further pooled results
Obesity, brain glucose metabolism in fasting states
- Obesity not associated with brain hypometabolism in fasting states, contrary to T2D and other insulin resistance-related conditions
- 0.29 SD (SMD; 95% CI −.81 to 1.39)
Original publication
Relation of Insulin Resistance to Brain Glucose Metabolism in Fasting and Hyperinsulinemic States: A Systematic Review and Meta-analysis. J Clin Endocrinol Metab. Published 24 August 2024. doi:10.
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