Inadequate Glucagon Suppression During Oral Glucose Tolerance Test (OGTT) in Prediabetes: A Systematic Review and Meta-analysis
Authors' conclusion
Glucagon was not adequately suppressed during OGTT in preDM. Glucagon dysregulation is a contributing mechanism underlying both IFG and IGT.
Study context
- Population
- Studies assessing glucagon levels during 75 g OGTT in both preDM and normal glucose tolerance (NGT) cohorts (Pubmed, Embase, Web of Science, Cochrane Library)
- Comparison
- PreDM vs NGT
- Outcome
- Glucagon levels in the fasting state and response to glucose inhibition during OGTT
Methodological detailsrandom-effect model
- Random-effect model
Pooled result
As reported in the abstract
Glucagon during OGTT
- Glucagon decreased in both preDM and NGT upon glucose challenge
- Glucagon at 0, 0.5, 1 and 1.5 h significantly higher in preDM vs NGT
- Glucose higher in preDM at all time points; insulin higher at 0, 1, 1.5 and 2 h
Further pooled results
Glucagon by assay method (subgroup)
- Radioimmunoassay studies: glucagon higher in preDM at 0.5 h and 1 h vs NGT
- ELISA studies: glucagon similar to NGT despite higher glucose in preDM
Glucagon in impaired glucose tolerance (IGT) and impaired fasting glucose (IFG)
- Fasting glucagon inadequately suppressed in both IGT and IFG
- Responsiveness to glucose inhibition preserved in IFG
- IGT: glucagon at 0.5 h not suppressed and higher than NGT
Original publication
Inadequate Glucagon Suppression During OGTT in Prediabetes: A Systematic Review and Meta-analysis. J Clin Endocrinol Metab. Published 4 July 2024. doi:10.
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