Aggravating effect of abnormal low-density protein cholesterol level on coronary atherosclerotic plaque in type 2 diabetes mellitus patients assessed by coronary computed tomography angiography
Authors' conclusion
Abnormal LDL-C levels aggravate atherosclerotic cardiovascular disease (ASCVD) in patients with T2DM. Clinical attention deserves to be caught by the tailored identification of cardiovascular risk categories in T2DM individuals and the achievement of the corresponding LDL-C treatment goal.
Study context
- Population
- T2DM patients assessed by coronary computed tomography angiography (CCTA), September 2011 to February 20223,439 collected
- Participants
- 2,820 patients
- Exposure
- Abnormal vs normal LDL-C level
- Abnormal LDL-C leveln = 1,847
- Normal LDL-C leveln = 973reference
- Outcome
- Coronary plaque characteristics assessed by CCTA
Main finding
As reported in the abstract
Coronary plaque characteristics (per-patient and per-segment)
- Low attenuation plaque; multivariable linear stepwise regression
- β 0.116; all P value < 0.001
- Positive remodelling
- β 0.138; all P value < 0.001
- Spotty calcification
- β 0.091; all P value < 0.001
- Nonobstructive stenosis (NOS)
- β 0.427; all P value < 0.001
- Obstructive stenosis (OS)
- β 0.659; all P value < 0.001
- Segment involvement scores (SIS)
- β 1.114; all P value < 0.001
- Segment stenosis score (SSS)
- β 2.987; all P value < 0.001
- Plaque involvement degree (PID)
- β 2.716; all P value < 0.001
Observational data: associations, not effects.
Original publication
Aggravating effect of abnormal low-density protein cholesterol level on coronary atherosclerotic plaque in type 2 diabetes mellitus patients assessed by coronary computed tomography angiography. Cardiovasc Diabetol. Published 4 July 2024. doi:10.
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