The association between the triglyceride–glucose index and vulnerable plaques in patients with type 2 diabetes mellitus: insights from coronary computed tomography angiography
Main finding · Vulnerable plaquesResult — go to the resultOdds ratio 1.23 95% CI 1.00–1.51Authors' conclusion
The TyG index was independently associated with vulnerable plaques of the coronary artery among patients with T2DM. The TyG index could be regarded as a marker to reduce the incidence of cardiovascular events in the targeted population of T2DM patients.
Study context
- Population
- T2DM patients who underwent coronary CT angiography (coronary computed tomography angiography (CCTA)) at West China Hospital, February 2017 to February 2022
- Participants
- 2,056 patients
- Exposure
- TyG index quartiles
- Outcome
- Presence of vulnerable plaques (at least two high-risk features within the same lesion) on CCTA
Methodological detailssingle-centre, TyG index quartiles
- Single-centre
- TyG index quartiles
Main finding
Vulnerable plaques
Odds ratio
1.23
95% CI 1.00–1.51
P = 0.046
TyG index
OR 1.23 (95% CI 1.00–1.51); P = 0.046
As reported in the abstract
Observational data: associations, not effects.
Further findings
Plaque type and high-risk features across TyG quartiles
- Higher TyG index: more noncalcified and mixed plaques, high-risk plaque features, vulnerable plaques and fewer calcified plaques
- P < 0.05 for all
- Proportion with low-attenuation noncalcified plaques, positive remodeling and napkin ring sign associated with TyG index
- P for trend < 0.05 for all
Vulnerable plaques by subgroup (age, CVD symptoms)
- Association between TyG index and vulnerable plaques varied with age and prevalence of CVD symptoms
- P for interaction < 0.05 for both
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The association between the triglyceride–glucose index and vulnerable plaques in patients with type 2 diabetes mellitus: insights from coronary computed tomography angiography. Cardiovasc Diabetol. Published 16 April 2025. doi:10.
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