Type 2 & other diabetes

A different perspective on studying stroke predictors: joint models for longitudinal and time-to-event data in a type 2 diabetes mellitus cohort

Cardiovasc DiabetolPublished Prognostic cohort study

Authors' conclusion

Age, AF, and SBP have been confirmed as significant predictive factors in both sexes, whereas renal function was significant only in women. Interestingly, an increase in DBP may serve as a protective factor in our cohort. These factors were particularly relevant in the last 3-7 years of follow-up.

Study context

Population
Patients with T2D and no history of stroke, transient ischemic attack (TIA) or MI, followed for 12 years
Participants
3,442 patients
Comparison
Men vs Women
Outcome
First stroke or TIA
Follow-up
12 years
Methodological detailsjoint models for longitudinal and time-to-event data, sex-specific models
  • Joint models for longitudinal and time-to-event data
  • Sex-specific models

Performance

As reported in the abstract

First stroke/TIA · follow-up period

Patients with first stroke/TIA

303

8.8%

AUC of both models

>0.70

Original publication

A different perspective on studying stroke predictors: joint models for longitudinal and time-to-event data in a type 2 diabetes mellitus cohort. Cardiovasc Diabetol. Published 16 April 2025. doi:10.1186/s12933-025-02713-9

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