The impact of sex-related disparities on the association between triglyceride-glucose index and renal function decline in patients with type 2 diabetes: Insights from the ACCORD trial
Primary result · CKD risk in womenResult — go to the resultAHR (Model 3), women 1.46 95 % CI 1.13–1.88Authors' conclusion
A higher TyG index was associated with elevated CKD risk and accelerated eGFR decline, particularly in women.
Study context
- Population
- Patients with T2D in the ACCORD trial
- Participants
- 9,360 patients
- Comparison
- Triglyceride-glucose (TyG) index tertiles T3 and T2 vs T1, by sex
- T1n = 3,119reference
- T2n = 3,121
- T3n = 3,120
- Primary endpoint
- CKD
- Follow-up
- Median 4 years
Methodological detailstertiles of TyG index, Cox proportional hazards model, generalized additive mixed models
- Tertiles of TyG index
- Cox proportional hazards model
- Generalized additive mixed models
Primary result
CKD risk in women
AHR (Model 3), women
1.46
95 % CI 1.13–1.88
P = 0.03 for interaction
T3vs T1
aHR (Model 3), women 1.46 (95 % CI 1.13–1.88); P for interaction = 0.03
As reported in the abstract
- Chronic kidney disease (CKD) cases overall
- 1 229 (13.30 %)
Further findings
mL/min/1.73 m²
| Outcome | T1 | T3 | P value |
|---|---|---|---|
| eGFR decline in women (longitudinal analysis)T3 vs T1 · more rapid decline with T3; not in men | −3.07 | −4.79 | P < 0.05 |
Original publication
The impact of sex-related disparities on the association between triglyceride-glucose index and renal function decline in patients with type 2 diabetes: Insights from the ACCORD trial. Diabetes Res Clin Pract. Published 16 April 2025. doi:10.
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