Reference Intervals for 24-Hour Urinary Calcium Excretion and Its Association With Bone Metabolism: A Multicenter Study
Authors' conclusion
This study established reference intervals for 24-hour UCaE in the Chinese population. This study found gender differences in the relationship between 24-hour UCaE and bone metabolism.
Study context
- Population
- Participants undergoing physical examinations at 9 tertiary hospitals, Chinese population
- Participants
- 1,239 participants
- Exposure
- Men vs Women
- Outcome
- Distribution of 24-hour urinary calcium excretion (UCaE) and its association with bone metabolism
Methodological detailsmulticenter, 9 tertiary hospitals
- Multicenter
- 9 tertiary hospitals
Main finding
As reported in the abstract
24-hour UCaE median
- 24-hour urinary calcium excretion (UCaE) median, overall
- 2.27 mmol
Observational data: associations, not effects.
Further findings
Prevalence of hypercalciuria
- Prevalence of hypercalciuria — Overall
- 11.6%
- Prevalence of hypercalciuria — Significantly varied across age groups and regions
- P < .05
24-hour UCaE/Ucr by age, men
- Highest, aged 30–44 years (median)
- 0.70
- Lowest, aged 18–29 years (median)
- 0.46
- Women: gradual increase with advancing age
Association of 24-hour UCaE/Ucr with bone metabolism (adjusted model)
- Independent positive association with 25(OH)D, men
- P = 0.032
- Independent positive association with 25(OH)D, women
- P < 0.001
- Independent association with parathyroid hormone (PTH), men
- P = 0.031
- Independent association with β-CTX, men
- P = 0.021
- Independent association with P1NP, men
- P = 0.048
- No association with PTH, β-CTX or P1NP in women
Original publication
Reference Intervals for 24-Hour Urinary Calcium Excretion and Its Association With Bone Metabolism: A Multicenter Study. J Clin Endocrinol Metab. Published 28 February 2025. doi:10.
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