Moderate salt restriction in primary aldosteronism improves bone metabolism through attenuation of urinary calcium and phosphate losses
Authors' conclusion
Salt restriction in PA limits urinary calcium and phosphate losses and may confer favorable osteoanabolic effects.
Study context
- Population
- Patients with primary aldosteronism (PA) on stable mineralocorticoid receptor antagonist therapy
- Participants
- 41 patients
- Exposure
- Moderate salt restriction, before vs after 12 weeks
- Salt restrictionn = 41
- Outcome
- Bone metabolism and electrolytes after salt restriction
- Follow-up
- 12 weeks
Methodological detailssingle-group, 12-week salt restriction
- Single-group
- 12-week salt restriction
Main finding
As reported in the abstract
12 weeks
- Urinary calcium and phosphate decreased
- Plasma testosterone, serum phosphate and bone alkaline phosphatase (BAP) increased significantly
Observational data: associations, not effects.
Further findings
Determinants of longitudinal BAP changes
- Changes in BAP independently correlated with changes in serum phosphate, PTH and urinary calcium in multivariate analysis
Original publication
Moderate salt restriction in primary aldosteronism improves bone metabolism through attenuation of urinary calcium and phosphate losses. Eur J Endocrinol. Published 1 April 2024. doi:10.
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