A Novel Method for the Evaluation of Hypercalciuria in Individuals With Chronic Hypoparathyroidism
Authors' conclusion
ECa/Ccr correlates with 24uCa in patients with chronic hypoparathyroidism. The lowest ECa/Ccr cutoff values ensure that hypercalciuria is not missed. Sufficiently high ECa/Ccr supports presence of hypercalciuria.
Study context
- Population
- Adults with chronic hypoparathyroidism managed with conventional therapy; all received palopegteriparatide (TransConPTH) in the open-label extension (OLE)
- Participants
- 59 adults
- Comparison
- ECa/Ccr vs 24-hour urine calcium to detect hypercalciuria
- Outcome
- Diagnostic accuracy of ECa/Ccr for hypercalciuria (24uCa >300 mg/d) by ROC analysis
Methodological detailspost-hoc analysis of the PaTH Forward trial, randomized, double-blind, placebo-controlled 4-week period followed by open-label extension
- Post-hoc analysis of the PaTH Forward trial
- Randomized, double-blind, placebo-controlled 4-week period followed by open-label extension
Performance
As reported in the abstract
Diagnostic accuracy of ECa/Ccr for hypercalciuria (24uCa >300 mg/d)
| Test or model | AUC | PPV of ECa/Ccr ≥ 0.149 mg/dL when pretest probability high | NPV at all cutoffs when pretest probability low |
|---|---|---|---|
| ECa/Ccr | 0.837 | ≥92% | ≥97% |
ECa/Ccr
AUC0.837
PPV of ECa/Ccr ≥ 0.149 mg/dL when pretest probability high≥92%
NPV at all cutoffs when pretest probability low≥97%
Further findings
- 24uCa · baseline
- 381 · Median · IQR 296–602 · mg/d
- 24uCa — 24uCa declined during OLE
- 61% to 72%
- ECa/Ccr · baseline
- 0.249 · Mean · SD 0.131 · mg/dL
- ECa/Ccr — ECa/Ccr fell during OLE
- 47% to 62%
Original publication
A Novel Method for the Evaluation of Hypercalciuria in Individuals With Chronic Hypoparathyroidism. Endocr Pract. Published 6 May 2026. doi:10.
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