Optimizing Parathyroid Localization in Real Life: The Role of Expert‐Performed Ultrasonography
Authors' conclusion
Expert-performed US should be considered the primary imaging modality for guiding MIP. Surgeons should consider referring patients to an expert ultrasonographer in cases of suspected ectopic adenoma, presence of multiglandular disease, before referring to 4D-CT scans or when considering bilateral neck explorations.
Study context
- Population
- Patients with PHPT who underwent surgery (minimally invasive parathyroidectomy (MIP)) and preoperative expert ultrasonography (US); tertiary referral center for endocrine surgery
- Participants
- 227 patients
- Comparison
- Expert US vs community US, 99mTc-MIBI, SPECT-CT and 4DCT for preoperative localization
- Outcome
- Accuracy (sensitivity, specificity, PPV) of expert US for preoperative localization in MIP
Methodological detailsretrospective, single-center
- Retrospective
- Single-center
Performance
As reported in the abstract
Preoperative parathyroid localization
| Test or model | Sensitivity | Specificity | PPV | Correctly localized adenomas |
|---|---|---|---|---|
| Expert US | 89% | 98% | 95% | 89% |
| Community US | 50% | 95% | ||
| MIBI | 75% | 95% | ||
| SPECT-CT | 82% | 96% | ||
| 4D-CT | 52% | 94% |
Sensitivity
Expert US89%
Community US50%
MIBI75%
SPECT-CT82%
4D-CT52%
Specificity
Expert US98%
Community US95%
MIBI95%
SPECT-CT96%
4D-CT94%
PPV
Expert US95%
Community US— not stated in the abstract
MIBI— not stated in the abstract
SPECT-CT— not stated in the abstract
4D-CT— not stated in the abstract
Correctly localized adenomas
Expert US89%
Community US— not stated in the abstract
MIBI— not stated in the abstract
SPECT-CT— not stated in the abstract
4D-CT— not stated in the abstract
Further findings
Prevalence of atypical cases
- Ectopic adenomas
- 25%
- Multiglandular disease
- 6%
Original publication
Optimizing Parathyroid Localization in Real Life: The Role of Expert‐Performed Ultrasonography. Clin Endocrinol (Oxf). Published 6 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →